FV4000MPE
Multiphoton Laser Scanning Microscope
Multiphoton Imaging Made Simple
The FV4000MPE microscope uses our advanced, silicon-based SilVIR™ detector that makes it easier than ever to acquire precise, reproducible data.
SilVIR Next-Generation Detector Technology
The SilVIR detector combines two advanced technologies—a silicon photomultiplier (SiPM) and our patented* fast signal processing design.
- High dynamic range
- Low noise
- No degradation of sensitivity
- Less sensitivity variation among other detectors
3D image of a live mouse brain from the surface to 900 µm deep using a TruResolution objective. The brighter neural cell body did not saturate thanks to the SilVIR detector’s high dynamic range.
Sample courtesy of: Aoi Gohma and Atsushi Miyawaki, RIKEN CBS-EVIDENT Open Collaboration Center.
Outstanding Multiphoton Images at Depth
The FV4000MPE microscope equipped with a TruResolution objective can efficiently excite fluorochromes deep in your sample by concentrating excitation laser power to achieve a brighter image. The advanced nondescanned (NDD) SilVIR detector has a larger beam diameter to better collect scattered fluorescence emissions from deeper in samples. The upgraded non-descanned detector (NDD) can be configured for a maximum of six channels for multicolor multiphoton imaging. Resonant scanner enables you to acquire large-volume 3D images quickly.
Stitched image of a cleared whole brain captured using 10X objective lens and resonant scanner (512x512 pixels. Z 501 slices, 225 positions). New resonant scanner has the ability to acquire equivalent quality images to galvo scanner in less than a third of the time.
Sample courtesy of: Tetsushi Hoshida and Atsushi Miyawaki, Laboratory for Cell Function Dynamics, RIKEN CBS.
Many Possibilities, One System
Depending on your application, you can choose between upright, gantry, or inverted microscope frames.
The FV4000MPE microscope is engineered to be modular, making it easy for you to configure the system based on your applications and budget.
You can start with a standard FV4000MPE and easily upgrade to a combo system by adding the SPE module as your research changes.
Upright Microscope System —
For in vivo and in vitro
multiphoton microscopy
Gantry Microscope System —
For in vivo observations that
require more space
Inverted Microscope System — For in vitro observation of 3D cell (spheroid) and tissue cultures
Experience the system’s innovations, including:
- Acquire accurate, quantitative image data from the macro scale to subcellular structures
- Gentler, higher-quality live in vivo imaging
- Obtain more information from a single multicolor image
- Monitor neuron and other essential dynamics with high-speed imaging
- Modular design to meet your ever-changing needs